Chip Reconstituting Organ - Level Lung Functions on a
نویسنده
چکیده
This copy is for your personal, non-commercial use only. . clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of June 24, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/328/5986/1662 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/328/5986/1662#otherarticles , 9 of which can be accessed for free: cites 41 articles This article http://www.sciencemag.org/cgi/collection/medicine Medicine, Diseases : subject collections This article appears in the following
منابع مشابه
Reconstituting organ-level lung functions on a chip.
Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicology studies, this lung mimic revealed that cyclic mechanical strain accentuates toxic and inf...
متن کامل3Rs and new frontiers in laboratory techniques.
Altex 31, 3/14 367 Huh, D., Matthews, B. D., Mammoto, A. et al. (2010). Reconstituting organ-level lung functions on a chip. Science 328, 1662-1668. http://dx.doi.org/10.1126/science.1188302 Huh, D., Leslie, D. C., Matthews, B. D. et al. (2012). A human disease model of drug toxicity – induced pulmonary edema in a lung-on-a-chip microdevice. Sci Trans Med 4, 159ra147. http://dx.doi.org/10.1126/...
متن کاملA human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.
Preclinical drug development studies currently rely on costly and time-consuming animal testing because existing cell culture models fail to recapitulate complex, organ-level disease processes in humans. We provide the proof of principle for using a biomimetic microdevice that reconstitutes organ-level lung functions to create a human disease model-on-a-chip that mimics pulmonary edema. The mic...
متن کاملHuman Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.
Here, we show that microfluidic organ-on-a-chip (organ chip) cell culture technology can be used to create in vitro human orthotopic models of non-small-cell lung cancer (NSCLC) that recapitulate organ microenvironment-specific cancer growth, tumor dormancy, and responses to tyrosine kinase inhibitor (TKI) therapy observed in human patients in vivo. Use of the mechanical actuation functionaliti...
متن کاملDesign of a Fuzzy Controller Chip with New Structure, Supporting Rational-Powered Membership Functions
In this paper, a new structure possessing the advantages of low-power consumption, less hardware and high-speed is proposed for fuzzy controller. The maximum output delay for general fuzzy logic controllers (FLC) is about 86 ns corresponding to 11.63 MFLIPS (fuzzy logic inference per second) while this amount of the delay in the designed fuzzy controller becomes 52ns that corresponds to 19.23 M...
متن کامل